The reason for using offset dowels/verniers is to optimise / correct the cam timing, quite often replacement cams are not ground 100% accurately with respect to the dowel hole/keyway which can cause the cam to be mistimed when assembled using just the standard timing marks. With OHC engines , skimming the head can affect cam timing too. Generally a cam manufacturer will give a lobe centre figure which represents the point at which the cam will gives its maximum lift, usually this is between 102 and 112 degrees after TDC, another quoted statisitic is the valve lift at TDC, either of these two methods can be used to correctly time the cam, personally I prefer the latter. In order to acheive correct timing it is necessary to be able to vary the cams timing WRT to the crank position, hence the offset dowels/keyways/verniers. The big disadvantage with offset dowels and keyways is that the pulleys have to be removed to replace them when timing the cams, with a vernier this is not necessary. A 244 cam has a lobe centre of 103 degrees on the inlet lobe, so it will give maximum lift at 103 degrees after TDC.
Assembly to the standard timing marks will get your cam timing near, but its worth checking where maximum valve lift is by using a protractor on the bottom pulley and a dial gauge on the appropriate cam follower.
Dave